| Evaluation of left ventricular function in long-term survivors of childhood Hodgkin disease. | |
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MedLine Citation:
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PMID: 15926158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Data on the presence of myocardial abnormalities in long-term Hodgkin disease survivors are contradictory. The purpose of this study was to determine if myocardial performance index (MPI) was capable of discovering cardiac abnormalities. PROCEDURE: Echocardiographic evaluation was performed in 31 survivors of Hodgkin disease (mean age 17.0 years), who received doxorubicin as part of chemotherapeutic treatment (median dose 164.8 +/- 42.5 mg/m(2)). Control group comprised 22 healthy subjects (mean age 16.7 years). RESULTS: Peak A velocity was increased (P = 0.004) and peak E/A velocity ratio was lower (P = 0.002) in patients compared to controls. Mean isovolumetric contraction time was longer in patients than in controls (P = 0.0001). Ejection time was significantly shorter in patients than in the controls (P = 0.001). Consequently, the MPI was significantly greater in the patients than in the controls (P = 0.0001). Abnormal MPI was found in 25/31 patients (83%). CONCLUSIONS: The Doppler-derived index of combined systolic and diastolic myocardial performance demonstrates the presence of subtle cardiac abnormalities in the majority of Hodgkin disease survivors. |
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Authors:
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Diana Iarussi; Carlo Pisacane; Paolo Indolfi; Fiorina Casale; Vincenzo Martino; Maria Teresa Di Tullio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 45 ISSN: 1545-5009 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-01 Completed Date: 2005-11-08 Revised Date: 2009-01-12 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 700-5 Citation Subset: IM |
Affiliation:
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Cattedra di Cardiologia, Dipartimento di Scienze Cardio-Chirurgiche, Toraciche e Respiratorie, Seconda Università di Napoli. dianal.iarussi@unina2.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Echocardiography* Female Hemodynamics Hodgkin Disease / complications, physiopathology* Humans Male Survivors Ventricular Dysfunction, Left / etiology, ultrasonography* Ventricular Function, Left* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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