Document Detail

Evaluation of left-to-right shunts in adults with atrial septal defect using first-pass radionuclide cardiography.
MedLine Citation:
PMID:  1600987     Owner:  NLM     Status:  MEDLINE    
Non-invasive determination of left-to-right shunts at the atrial level was performed by a new procedure using first-pass radionuclide measurement of cardiac output of the right and left ventricle. In 23 patients with coronary artery disease without shunt the mean difference between the cardiac outputs of the right and left ventricle was 0.04 l.min-1, the limits of agreement -0.80 to 0.88 l.min-1 and the 95% confidence interval for the bias -0.14 to 0.22 l.min-1. Right-sided cardiac catheterization was performed to assess the severity of the arterio-venous shunt by oximetry in 18 adult patients with atrial septal defects. The range of pulmonary-to-systemic flow ratios was 1.4 to 5.0 (mean 2.7) by oximetry and 1.3 to 4.4 (mean 2.5) by the radionuclide technique. The mean difference between flow ratios measured by the two methods was 0.25, the limits of agreement, -0.85 to 1.35 and the 95% confidence intervals for the bias -0.02 to 0.52. In two patients the difference in flow ratios was more than 1. In one of these the oximetric value was more than 2, and the radionuclide value less than 2. The limits of agreement between flow ratios determined by repeated measurements were -1.05 to 0.97, and by two independent observers -0.75 to 0.77. The present findings suggest that first-pass radionuclide determination of left-to-right shunts through atrial septal defects is both reproducible and accurate when compared to the oximetric technique.
H Kelbaek; J Aldershvile; J H Svendsen; S L Nielsen; O Munck; A Wennevold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  491-5     Citation Subset:  IM    
Department of Medicine B, Rigshospitalet, Herlev, Denmark.
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MeSH Terms
Cardiac Output / physiology*
Coronary Disease / radionuclide imaging
Heart Catheterization
Heart Septal Defects, Atrial / radionuclide imaging*
Middle Aged
Mitral Valve Insufficiency / radionuclide imaging
Reproducibility of Results
Ventriculography, First-Pass*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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