Document Detail


Evaluation of lead exposure in workers at secondary lead smelters in South Korea: with focus on activity of erythrocyte pyrimidine 5'-nucleotidase (P5N).
MedLine Citation:
PMID:  11886093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate lead exposure among secondary lead-smelting workers with a focus on erythrocyte pyrimidine 5'-nucleotidase (P5N) activity, blood lead concentration (PbB), activity of P5N and other biological variables were examined in 88 exposed workers in five secondary lead smelters and in 24 non-exposed workers in Korea. All of the mean values of air lead concentration (PbA) in the three processes, scrap pretreatment, blast furnace smelting, and refining and casting of the secondary lead smelters, markedly exceeded 0.05 mg/m3. In this survey, 29 (97%) of 30 air samples for lead exceeded 0.05 mg/m3. The highest mean PbA and PbB values were found in the section of blast furnace smelting. All of the mean PbB values in all the sections were higher than 30 microg/dl. PbB of 71 (81%) of the 88 exposed workers exceeded 30 microg/dl. In 31 (35%) of the exposed workers, PbB was above 60 microg/dl. Compared with the non-exposed group, zinc protoporphyrin (ZPP) in the exposed group was significantly increased, whereas erythrocyte P5N activity and activity of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) were significantly inhibited. Erythrocyte P5N activity had valid biological correlation with PbB and with other biological variables, such as ALAD activity or ZPP. Lead exposure affected hemoglobin levels via inhibition of P5N activity, as well as the heme biosynthetic pathway, in the high-exposure state.
Authors:
Yangho Kim; Hun Lee; Choong Ryed Lee; Dong Uk Park; Jeong Sun Yang; In Jeong Park; Kwang Yong Lee; MiYoung Lee; Tae-Kyun Kim; Nam-Seok Sohn; Young Sook Cho; NaRoo Lee; Ho Keun Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Science of the total environment     Volume:  286     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-11     Completed Date:  2002-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  181-9     Citation Subset:  IM    
Affiliation:
Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea. yanghokm@nuri.net
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MeSH Terms
Descriptor/Qualifier:
5'-Nucleotidase / metabolism*
Adult
Biological Markers / analysis
Erythrocytes / drug effects,  enzymology
Female
Heme / biosynthesis
Humans
Industry
Korea
Lead / adverse effects*,  analysis
Male
Middle Aged
Occupational Exposure*
Porphobilinogen Synthase / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 14875-96-8/Heme; 7439-92-1/Lead; EC 3.1.3.5/5'-Nucleotidase; EC 4.2.1.24/Porphobilinogen Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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