Document Detail


Evaluation of laser Doppler flowmetry to assess cyclosporine A-induced impairment of renal blood flow.
MedLine Citation:
PMID:  9655089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyclosporine A (CyA)-induced nephrotoxicity is a well-known complication of this potent immunosuppressive drug. It is caused by an elevation in renovascular resistance and impairment of renal blood flow. Currently, one of the principal experimental settings to assess renal hemodynamics has been using the in vivo fluorescent videomicroscopy (IVFV) method on hydronephrotic rat kidneys, which is expensive, time-consuming, not physiological, and not applicable to humans. In the present paper we have been able to confirm our working hypothesis that laser Doppler flowmetry (LDF) is a valuable tool for assessing microcirculatory changes in the rat kidney during CyA administration. Total subcapsular blood flow decreased to approximately 70% of baseline values (P < 0.05) and mean arterial pressure (MAP) increased initially to 113% of baseline values (P < 0.05) compared to only minor changes for cremophor (carrier substance) or no changes for sodium chloride solution 0.9%. LDF provides an easy and rapid technique and its major advantage is the potential use in assessing microcirculatory changes after kidney transplants in humans.
Authors:
M Naef; H U Baer; C Glaser; A M Wheatley; M K Schilling; C A Seiler; M W Büchler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of surgical research     Volume:  75     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
Affiliation:
Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclosporine / pharmacology*
Evaluation Studies as Topic
Immunosuppressive Agents / pharmacology*
Laser-Doppler Flowmetry / standards*
Male
Rats
Rats, Wistar
Renal Circulation / drug effects*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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