Document Detail


Evaluation of ketanserin as a tocolytic agent in third trimester pregnant rats.
MedLine Citation:
PMID:  2041454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ketanserin, as a 5HT2 selective antagonist, was evaluated for its tocolytic effects in pregnant Charles River (CR) rats, at total doses of 1.5 and 3.5 mg/kg IU from day 22 to day 25 of pregnancy. After 18 hours of ethenyl estradiol induction, tocolytic evaluation was carried out by recording uterine activity. When compared to the control group, the administration of Ketanserin resulted in an apparent, nondose dependent suppression of uterine contractility.
Authors:
N Zmira; M Manpach; D Varon; R Maymon; C Bahary
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  48     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1809-12     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology B, Sapir Medical Center, Kfar Saba, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bradycardia / chemically induced
Female
Ketanserin / adverse effects,  pharmacology*
Pregnancy
Pregnancy, Animal / drug effects*
Rats
Serotonin Antagonists / pharmacology
Tocolytic Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Serotonin Antagonists; 0/Tocolytic Agents; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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