Document Detail

Evaluation of ketanserin as a tocolytic agent in third trimester pregnant rats.
MedLine Citation:
PMID:  2041454     Owner:  NLM     Status:  MEDLINE    
Ketanserin, as a 5HT2 selective antagonist, was evaluated for its tocolytic effects in pregnant Charles River (CR) rats, at total doses of 1.5 and 3.5 mg/kg IU from day 22 to day 25 of pregnancy. After 18 hours of ethenyl estradiol induction, tocolytic evaluation was carried out by recording uterine activity. When compared to the control group, the administration of Ketanserin resulted in an apparent, nondose dependent suppression of uterine contractility.
N Zmira; M Manpach; D Varon; R Maymon; C Bahary
Related Documents :
1681744 - Progesterone and modulation of endothelium-dependent responses in canine coronary arter...
9728074 - Role of 17beta-estradiol in the modulation of baroreflex sensitivity in male rats.
10837984 - Effect of papaya latex extract on gravid and non-gravid rat uterine preparations in vitro.
18437124 - Ovariectomy, but not estrogen deficiency, increases cyp4a modulation of alpha(1)-adrene...
3147474 - Effects of pimozide, across doses and within sessions, on discriminated lever release p...
12794274 - Effect of aluminum on the blood-brain barrier permeability during nitric oxide-blockade...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  48     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1809-12     Citation Subset:  IM    
Department of Obstetrics and Gynecology B, Sapir Medical Center, Kfar Saba, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bradycardia / chemically induced
Ketanserin / adverse effects,  pharmacology*
Pregnancy, Animal / drug effects*
Serotonin Antagonists / pharmacology
Tocolytic Agents / pharmacology*
Reg. No./Substance:
0/Serotonin Antagonists; 0/Tocolytic Agents; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Primary mandibular reconstruction: analysis of 64 cases and evaluation of interface radiation dosime...
Next Document:  Cell cycle arrest and cellular differentiation mediated by a cell surface sialoglycopeptide.