| Evaluation of ketanserin as a tocolytic agent in third trimester pregnant rats. | |
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MedLine Citation:
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PMID: 2041454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ketanserin, as a 5HT2 selective antagonist, was evaluated for its tocolytic effects in pregnant Charles River (CR) rats, at total doses of 1.5 and 3.5 mg/kg IU from day 22 to day 25 of pregnancy. After 18 hours of ethenyl estradiol induction, tocolytic evaluation was carried out by recording uterine activity. When compared to the control group, the administration of Ketanserin resulted in an apparent, nondose dependent suppression of uterine contractility. |
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Authors:
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N Zmira; M Manpach; D Varon; R Maymon; C Bahary |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 48 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-07-08 Completed Date: 1991-07-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1809-12 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology B, Sapir Medical Center, Kfar Saba, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bradycardia / chemically induced Female Ketanserin / adverse effects, pharmacology* Pregnancy Pregnancy, Animal / drug effects* Rats Serotonin Antagonists / pharmacology Tocolytic Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Antagonists; 0/Tocolytic Agents; 74050-98-9/Ketanserin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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