Document Detail


Evaluation of ivermectin against later fourth-stage Strongylus vulgaris in ponies at two and five weeks after treatment.
MedLine Citation:
PMID:  6391639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of ivermectin against later fourth-stage Strongylus vulgaris larvae was studied in pony foals at 14 and 35 days after treatment. These foals had been reared parasite-free, inoculated with 500 infective larvae and 56 days later given either ivermectin at 200 micrograms/kg or a placebo intramuscularly. At necropsy, foals were examined for lesions and larvae grossly and histologically. Ivermectin was found to be highly effective (98.6%) against later fourth-stage larvae in five foals which were examined at 35 days after treatment, but not in five others examined at 14 days (72.5%). In some foals larvae were found in the tunica media of the ileocolic arteries. The conformation of these larvae appeared normal, but there were degenerative changes which suggested that they were dying or dead. Questions as to how the larvae attained that site and the consequences of their presence there were raised.
Authors:
J O Slocombe; B M McCraw
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of comparative medicine. Revue canadienne de médecine comparée     Volume:  48     ISSN:  0008-4050     ISO Abbreviation:  Can. J. Comp. Med.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0151747     Medline TA:  Can J Comp Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthelmintics / pharmacology*,  therapeutic use
Arteries / parasitology,  pathology
Clinical Trials as Topic / veterinary
Horses
Ivermectin
Lactones / pharmacology*,  therapeutic use
Larva / drug effects
Strongyle Infections, Equine / drug therapy,  parasitology*,  pathology
Strongyloidea / drug effects*
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Lactones; 70288-86-7/Ivermectin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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