Document Detail

Evaluation of ischemic heart disease on a 1.5 Tesla scanner: combined first-pass perfusion and viability study.
MedLine Citation:
PMID:  16012398     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We implemented a fast gradient echo (GRE) sequence with an echo-planar imaging (EPI) read-out (FGRE-ET) to conduct myocardial perfusion studies on a conventional scanner. The accuracy of combined perfusion and viability studies is evaluated in comparison with coronary angiography (CAG). MATERIALS AND METHODS: We enrolled 33 patients suspected of having coronary artery disease in this study. Short-axis perfusion images of the left ventricles were acquired following intravenous bolus injection of gadolinium-DTPA (0.05 mml/kg), both after myocardial loading by dipyridamole (0.56 mg/kg) and at rest. Viability studies were obtained using an inversion-recovery FGRE sequence. Radiologists performed blinded film readings. The findings with perfusion and the viability studies were compared with CAG on a segment-to-segment basis corresponding to the coronary arteries' territories. Stenosis equal to or greater than 75% in diameter was considered significant on CAG. The results were also compared with single photon emission computed tomography (SPECT) in 23 patients. RESULTS: The combination of perfusion and viability studies showed 85.7% sensitivity, 88.9% specificity, and 87.2% accuracy in comparison with CAG. SPECT revealed respective rates of 71.7%, 78.3%, and 73.9% in 23 patients of this group. CONCLUSION: Myocardial perfusion studies using FGRE-ET were feasible and accurate, even on a conventional scanner.
Shigeo Okuda; Akihiro Tanimoto; Toru Satoh; Jun Hashimoto; Hiroshi Shinmoto; Nobuya Higuchi; Atsushi Nozaki; Sachio Kuribayashi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  23     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-13     Completed Date:  2005-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  230-5     Citation Subset:  IM    
Department of Diagnostic Radiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
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MeSH Terms
Coronary Angiography
Dipyridamole / diagnostic use
Gadolinium DTPA / diagnostic use
Magnetic Resonance Imaging / methods*
Middle Aged
Myocardial Ischemia / diagnosis*,  radiography
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
58-32-2/Dipyridamole; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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