Document Detail

Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases.
MedLine Citation:
PMID:  19375269     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ischemia-modified albumin (IMA) has been shown to be a rapidly rising and sensitive biochemical marker for the diagnosis of myocardial ischemia. In this study, we evaluated the levels of IMA in myocardial infarction and prostate diseases, as well as the influence of HDL cholesterol levels on C-reactive protein (CRP) and IMA levels. METHODS: A total of 27 patients with myocardial infarction (MI), 102 patients with benign prostatic hyperplasia (BPH), 84 patients with prostate cancer (PCA), and 21 healthy subjects were enrolled in this study. IMA levels were measured in whole studied patients. Cardiac troponin I (cTnI), cholesterol, HDL cholesterol, and CRP were measured in MI and control groups. RESULTS: IMA values were significantly higher in patients with MI (0.5215+/-0.0241 ABSU) and BPH (0.4150+/-0.0156 ABSU) in comparison to control subjects (0.3381+/-0.0194 ABSU). IMA and CRP were higher in MI group, especially in patients with HDL cholesterol levels lower than 38 mg/dL. The ability of IMA to discriminate myocardial infarction was higher than CRP. Significant correlations between CRP and HDL, CRP and IMA, and HDL and IMA were reported. CONCLUSIONS: IMA and CRP increase in myocardial damage, and the decrease of HDL cholesterol appears to enhance the inflammatory response. IMA also increase in benign prostate hyperplasia and this finding suggests that the diagnosis of prostate diseases must be considered on evaluation of IMA as a marker of cardiac ischemia.
Aline K Mastella; Rafael N Moresco; Dievan Bisognin da Silva; Aline M Becker; Marta M M F Duarte; Let??cia L Giovelli; Sandra Huber da Silva; Luana Rossato; Maria B Moretto; Jos?? E Paz da Silva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-20
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biom??decine & pharmacoth??rapie     Volume:  63     ISSN:  1950-6007     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  762-6     Citation Subset:  IM    
Department of Clinical and Toxicological Analysis, Centre of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
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MeSH Terms
Aged, 80 and over
Biological Markers / metabolism
C-Reactive Protein / metabolism
Cholesterol, HDL / blood
Ischemia / pathology
Middle Aged
Myocardial Infarction / diagnosis,  physiopathology*
Prospective Studies
Prostatic Hyperplasia / diagnosis,  physiopathology*
Prostatic Neoplasms / diagnosis,  physiopathology*
Sensitivity and Specificity
Serum Albumin / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Serum Albumin; 9007-41-4/C-Reactive Protein

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