| Evaluation of ischemia-modified albumin in anemia associated to chronic kidney disease. | |
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MedLine Citation:
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PMID: 18200583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic kidney disease (CKD) is highly prevalent, with increasing numbers of patients affected by the disease world-wide, and anemia is a common finding in patients with CKD. Anemia impacts negatively on cardiovascular disease, exercise capacity, and quality of life, resulting in significant mortality and morbidity. The aim of this study was to evaluate the levels of ischemia-modified albumin and lactate in patients with established anemia associated with CKD and its correlations with hemoglobin levels. Hematocrit, hemoglobin, iron, ferritin, albumin, creatinine, lactate, and ischemia-modified albumin (IMA) were measured in 17 patients with established anemia associated to CKD and 19 controls by standard methods. The results of hematocrit, hemoglobin, iron, and albumin were lower in the anemia group than in the control group. Ferritin, creatinine, and lactate levels were higher in anemia of the CKD group than the control group. IMA increase in the anemia group (0.8115+/-0.1304 absorbance units [ABSU]) compared to control (0.4951+/-0.0393 ABSU). Significant correlations between IMA and lactate, IMA and hemoglobin, IMA and creatinine, and hemoglobin and lactate were observed. IMA and lactate increase during anemia and this elevation could be associated to hypoxia due to low hemoglobin levels. However, our data suggest that lactate is more sensitive to anemia compared to IMA. |
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Authors:
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Luiz Carlos Cichota; Rafael Noal Moresco; Marta Maria Medeiros Frescura Duarte; José Edson Paz da Silva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical laboratory analysis Volume: 22 ISSN: 0887-8013 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-01-23 Completed Date: 2008-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: United States |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley-Liss, Inc. |
Affiliation:
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Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia / blood*, complications* Case-Control Studies Creatinine / blood Female Hemoglobins / analysis, metabolism Humans Ischemia / blood*, complications* Kidney Failure, Chronic / blood*, complications* Lactic Acid / blood Male Middle Aged Serum Albumin / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Serum Albumin; 50-21-5/Lactic Acid; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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