| Evaluation of intubating conditions with rocuronium and either propofol or etomidate for rapid sequence induction. | |
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MedLine Citation:
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PMID: 9771181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have assessed the effect of two induction agents on tracheal intubating conditions after rocuronium 0.6 mg.kg-1 in unpremedicated patients undergoing simulated rapid sequence induction. Following pre-oxygenation, anaesthesia was induced with propofol up to 2.5 mg.kg-1 (n = 35) or etomidate 0.3 mg.kg-1 (n = 36), and further increments as required. After loss of verbal contact, cricoid pressure was applied and rocuronium was injected. Laryngoscopy was performed at 45 s and intubation attempted at 60 s after rocuronium had been given. Ninety-four per cent of patients in the propofol group had clinically acceptable (good or excellent) intubating conditions compared to only 75% in the etomidate group (p = 0.025). Owing to coughing, one patient in the etomidate group could not be intubated on the first attempt. A greater pressor response also followed intubation after induction with etomidate. We conclude that etomidate and rocuronium alone cannot be recommended for intubation at 60 s under rapid sequence induction conditions. |
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Authors:
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H J Skinner; A Biswas; R P Mahajan |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 53 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-10-21 Completed Date: 1998-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 702-6 Citation Subset: AIM; IM |
Affiliation:
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Nottingham City Hospital NHS Trust, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Androstanols* Anesthetics, Intravenous* / pharmacology Blood Pressure / drug effects Double-Blind Method Etomidate / pharmacology Female Heart Rate / drug effects Humans Intubation, Intratracheal* Male Middle Aged Neuromuscular Nondepolarizing Agents* Propofol / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Androstanols; 0/Anesthetics, Intravenous; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium; 2078-54-8/Propofol; 33125-97-2/Etomidate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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