Document Detail

Evaluation of intubating conditions with rocuronium and either propofol or etomidate for rapid sequence induction.
MedLine Citation:
PMID:  9771181     Owner:  NLM     Status:  MEDLINE    
We have assessed the effect of two induction agents on tracheal intubating conditions after rocuronium 0.6 in unpremedicated patients undergoing simulated rapid sequence induction. Following pre-oxygenation, anaesthesia was induced with propofol up to 2.5 (n = 35) or etomidate 0.3 (n = 36), and further increments as required. After loss of verbal contact, cricoid pressure was applied and rocuronium was injected. Laryngoscopy was performed at 45 s and intubation attempted at 60 s after rocuronium had been given. Ninety-four per cent of patients in the propofol group had clinically acceptable (good or excellent) intubating conditions compared to only 75% in the etomidate group (p = 0.025). Owing to coughing, one patient in the etomidate group could not be intubated on the first attempt. A greater pressor response also followed intubation after induction with etomidate. We conclude that etomidate and rocuronium alone cannot be recommended for intubation at 60 s under rapid sequence induction conditions.
H J Skinner; A Biswas; R P Mahajan
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  53     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-21     Completed Date:  1998-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  702-6     Citation Subset:  AIM; IM    
Nottingham City Hospital NHS Trust, UK.
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MeSH Terms
Anesthetics, Intravenous* / pharmacology
Blood Pressure / drug effects
Double-Blind Method
Etomidate / pharmacology
Heart Rate / drug effects
Intubation, Intratracheal*
Middle Aged
Neuromuscular Nondepolarizing Agents*
Propofol / pharmacology
Reg. No./Substance:
0/Androstanols; 0/Anesthetics, Intravenous; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium; 2078-54-8/Propofol; 33125-97-2/Etomidate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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