| Evaluation of intraosseous delivery of factor VIIa during hemorraghic shock in the pig. | |
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MedLine Citation:
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PMID: 19317190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this investigation is to determine if intraosseous infusion (IO) is a suitable method for the delivery of recombinant human factor VIIa (rFVIIa) during hemorrhagic shock. The measures that were used to evaluate IO delivery suitability included: (1) determination of clinically significant local or systemic toxicity and (2) demonstration that systemic blood levels of rFVIIa increased rapidly following administration. Our results indicate that there was no evidence of significant local or systemic toxicity following infusion and that the systemic blood concentration of rFVIIa peaks immediately after the end of infusion. This result suggests that the systemic blood level profiles of rFVIIa delivered by IO infusion are similar to those that could be produced by intravenous (IV) administration. Furthermore, in all 25 test animals, access to the systemic circulation during shock was achieved as evidenced by rapid increase in a marker dye (flourescein) or rFVIIa in the blood. We conclude that administration of rFVIIa via IO infusion is a reasonable safe method and is likely to produce blood levels required for improved hemostasis during shock. |
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Authors:
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James K Wright; Robert J Christy; Robert V Tharp; John E Kalns |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Military medicine Volume: 174 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-03-25 Completed Date: 2009-05-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: United States |
Other Details:
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Languages: eng Pagination: 119-23 Citation Subset: IM |
Affiliation:
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720th Special Tactics Group, Air Force Special Operations Command, Hurlburt Field, FL 32544, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Dose-Response Relationship, Drug Factor VIIa / administration & dosage*, pharmacokinetics Infusions, Intraosseous* Outcome Assessment (Health Care)* Recombinant Proteins / administration & dosage, pharmacokinetics Shock, Hemorrhagic / drug therapy* Swine |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 0/recombinant FVIIa; EC 3.4.21.21/Factor VIIa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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