| Evaluation of intervention to prevent hypomagnesemia in cervical cancer patients receiving combination cisplatin and radiation treatment. | |
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MedLine Citation:
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PMID: 19172305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to evaluate the impact of increasing the magnesium (Mg(2+)) supplementation in the pre- and posthydration of patients receiving cisplatin plus radiation (CisXRT) to prevent chemotherapy-induced hypomagnesemia (CIH) events. MATERIALS AND METHODS: The study was conducted on newly diagnosed cervical cancer patients receiving CisXRT. The first prospective intervention to prevent CIH was to increase the pre- and posthydration Mg(2+) from 1 to 2 g. After completion of the first intervention, the analysis demonstrated the persistent occurrence of CIH on cycle 3, and later, a second intervention was implemented to increase Mg(2+) to 3 g in the pre- and posthydration. Patients that failed to complete at least five cycles or received cisplatin in combination with another chemotherapy regimen were excluded from the study. Baseline group included 70 patients that had received CisXRT prior to any changes in magnesium supplementation. RESULTS: There were 62.8% (44/70) and 32.6% (22/70) of patients with episodes of CIH in the baseline and first intervention groups, respectively (P = 0.007). In the second intervention group, a 49.6% decrease in the total number of episodes compared to control group was observed. Patients in the second intervention group showed a 100% improvement incidence of persistent CIH over the two other cohorts (P = 0.001). CONCLUSIONS: The increase of Mg(2+) to 2 g for the initial two cycles and then to 3 g with the third cycle of CisXRT therapy prevented episodes of CIH and decreased associated treatment delays. |
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Authors:
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Rodney J Hunter; Makala B Pace; Kimberly A Burns; Catherine C Burke; Deborah A Gonzales; Nicki F Webb; Charles F Levenback; Anuja Jhingran; Crystal Parker; Mark F Munsell; Judith A Smith |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-01-27 |
Journal Detail:
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Title: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Volume: 17 ISSN: 1433-7339 ISO Abbreviation: Support Care Cancer Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-14 Completed Date: 2009-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9302957 Medline TA: Support Care Cancer Country: Germany |
Other Details:
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Languages: eng Pagination: 1195-201 Citation Subset: IM |
Affiliation:
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Division of Pharmacy, The University of Texas M.D. Anderson Cancer Center, CPB6.3244, 1155 Herman Pressler, Unit 1362, Houston, TX 77230, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / administration & dosage, adverse effects* Cisplatin / administration & dosage, adverse effects* Female Humans Magnesium / administration & dosage Magnesium Deficiency / chemically induced, prevention & control* Middle Aged Prospective Studies Radiotherapy, Adjuvant / adverse effects Uterine Cervical Neoplasms / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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