Document Detail

Evaluation of interleukin 13 polymorphisms in systemic sclerosis.
MedLine Citation:
PMID:  16832637     Owner:  NLM     Status:  MEDLINE    
Systemic sclerosis (SSc) is a multisystem disease of unknown etiology. It is characterized by excessive cutaneous and visceral fibrosis, damage to small blood vessels, and production of autoantibodies. Interleukin-13 (IL-13) has been shown to be involved in abnormal fibrosis in other diseases. Therefore, we have evaluated its possible involvement in SSc. We analyzed four IL13 gene polymorphisms, rs1800925 (IL13-1055), rs20541 (Arg130Gln), rs847, and rs2243204 in 107 unrelated SSc patients (40 patients having diffuse cutaneous form and 67 patients having limited cutaneous form) and in 170 controls. All subjects were Caucasians. In the total patient population and in the diffuse cutaneous subset, we observed an association between two IL13 polymorphisms, IL13 rs1800925 (IL13-1055), and IL13 rs2243204, and disease (p=0.03-0.04). The IL13 rs2243204T allele was more common in SSc patients (p=0.01, OR=2.3 CI 1.21-4.38) and in the diffuse cutaneous form (p=0.01, OR=2.95, CI 1.35-6.49) than in control subjects. Our result supports the suggestion that polymorphisms in IL13 are associated to SSc and skin fibrosis process. However, further studies on larger and independent population and functional analyses are needed to confirm these findings.
Brigitte Granel; Christophe Chevillard; Yannick Allanore; Violaine Arnaud; Sandrine Cabantous; Sandrine Marquet; Pierre-Jean Weiller; Jean-Marc Durand; Jean-Robert Harlé; Claire Grange; Yves Frances; Philippe Berbis; Jean Gaudart; Philippe de Micco; André Kahan; Alain Dessein
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-11
Journal Detail:
Title:  Immunogenetics     Volume:  58     ISSN:  0093-7711     ISO Abbreviation:  Immunogenetics     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0420404     Medline TA:  Immunogenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  IM    
Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, UMR 399 INSERM, Université de la Méditerranée, Faculté de Médecine, 13005, Marseille, France.
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MeSH Terms
Case-Control Studies
Interleukin-13 / genetics*
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Scleroderma, Systemic / blood,  genetics*
Skin / pathology
Reg. No./Substance:

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