Document Detail

Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinical Trials Group (ACTG).
MedLine Citation:
PMID:  9597244     Owner:  NLM     Status:  MEDLINE    
This study examined whether adding levofloxacin to a standard four-drug regimen improved the 8-week culture response and compared effectiveness of 9 versus 6 months of intermittent therapy for human immunodeficiency virus-related pansusceptible pulmonary tuberculosis. Patients were randomized to receive either four or five drugs, the fifth being levofloxacin. Patients who completed induction therapy were randomized to complete 9 versus 6 months of intermittent therapy with isoniazid and rifampin. In the randomized induction phase, 97.3% of patients in the four-drug group and 95.8% in the five-drug group had sputum culture conversion at 8 weeks (P = 1.00). In the continuation phase, one patient (2%) assigned to 9 months and two patients (3.9%) assigned to 6 months of therapy had treatment failure/relapse (P = 1.00). In conclusion, this study showed that levofloxacin added no benefit to a highly effective, largely intermittent, four-drug induction regimen. Both 9 and 6 months of intermittent therapy were associated with low treatment failure/relapse rates.
W M el-Sadr; D C Perlman; J P Matts; E T Nelson; D L Cohn; N Salomon; M Olibrice; F Medard; K D Chirgwin; D Mildvan; B E Jones; E E Telzak; O Klein; L Heifets; R Hafner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  26     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-16     Completed Date:  1998-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1148-58     Citation Subset:  IM; X    
Division of Infectious Disease, Harlem Hospital Center, New York, New York 10037, USA.
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MeSH Terms
AIDS-Related Opportunistic Infections / drug therapy*
Antitubercular Agents / administration & dosage,  therapeutic use*
Drug Administration Schedule
Drug Therapy, Combination
Ethambutol / administration & dosage,  therapeutic use
Isoniazid / administration & dosage,  therapeutic use
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects,  isolation & purification
Ofloxacin / administration & dosage,  therapeutic use*
Pyrazinamide / administration & dosage,  therapeutic use
Rifampin / administration & dosage,  therapeutic use
Sputum / microbiology
Treatment Outcome
Tuberculosis, Pulmonary / drug therapy*
Reg. No./Substance:
0/Antitubercular Agents; 13292-46-1/Rifampin; 54-85-3/Isoniazid; 74-55-5/Ethambutol; 82419-36-1/Ofloxacin; 98-96-4/Pyrazinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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