| Evaluation of induction doses of propofol: comparison between endstage renal disease and normal renal function patients. | |
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MedLine Citation:
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PMID: 12413256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anaemia, hypoproteinaemia and acidic pH in renal failure patients can alter the pharmacokinetics and pharmacodynamics of anaesthetic agents, resulting in altered dose requirements. We evaluated the induction dose of propofol in adult patients with end-stage renal disease by titrating the hypnotic effect by means of a clinical parameter as well as using a more objective assessment of hypnosis, the Bispectral Index (BIS) monitor. The dose was compared with that for patients with normal renal function. Propofol doses that provided the clinical end-point of hypnosis (syringe drop method), as well as the end-point of a mean (SD) BIS value of 50 (5), were evaluated in 27 end-stage renal disease and 27 normal renal function patients. Propofol was administered at 0.2 mg/kg every 15 seconds until these end-points were achieved. End-stage renal disease patients required significantly higher propofol doses to achieve the clinical end-point of hypnosis (1.42 (0.24) mg/kg versus 0.89 (0.2) mg/kg in normal renalfunction patients, P<0.05 unpaired "t" test). Propofol dose required to achieve a BIS of 50 (5) was also higher in end-stage renal disease patients (2.03 (0.4) mg/kg versus 1.39 (0.43) mg/kg in normal renal function patients, P<0.05). There was a significant negative correlation of propofol dose with preoperative haemoglobin concentration. A hyperdynamic circulation in renal failure patients with anaemia may be responsible for the higher propofol dose requirement in this group. |
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Authors:
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P Goyal; G D Puri; C K Pandey; S Srivastva |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 30 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-04 Completed Date: 2003-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: Australia |
Other Details:
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Languages: eng Pagination: 584-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia Recovery Period Anesthesia, Intravenous / methods Anesthetics, Intravenous / administration & dosage* Case-Control Studies Dose-Response Relationship, Drug Female Humans Kidney Failure, Chronic / diagnosis*, surgery Kidney Function Tests Kidney Transplantation / methods Male Middle Aged Monitoring, Intraoperative Preoperative Care Probability Propofol / administration & dosage*, adverse effects Reference Values Regression Analysis Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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