| Evaluation of the in vivo efficacy of a new vaginal contraceptive agent in stumptailed macaques. | |
| | |
MedLine Citation:
|
PMID: 6698237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of precoital vaginal placement of three spermicidal formulations on postcoitally recovered vaginal and cervical spermatozoa was compared. Periovulatory stumptailed macaque monkeys were administered intravaginally 1 ml of Ramses Contraceptive Vaginal Jelly (C. Schmid Products Company, Little Fall, NJ), or a pluronic gel formulation containing 0, 0.1, or 1.0% of a new spermicidal compound, RS-37367. All spermicide-containing formulations reduced the motility of both vaginal and cervical sperm, compared with the gel containing no spermicide. The 1.0% RS-37367 formulation was particularly effective. No motile spermatozoa were recovered from either location, and only 0.5% of the numbers of cervical spermatozoa recovered in control animals were recoverable from this treatment group (P less than 0.0003). The formulation containing 0.1% RS-37367 appeared to be bioequivalent to the Ramses formulation containing 5% nonoxynol-9. These in vivo results support previous in vitro comparisons in which RS-37367 was estimated to be 50 times as potent a spermatostatic agent as nonoxynol-9. |
| | |
Authors:
|
L J Zaneveld; J W Burns; J C Goodpasture; B H Vickery |
Related Documents
:
|
15305997 - A non-invasive method for measurement of gastric emptying in mice: effects of altering ... 21931647 - Dha supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it... 7501597 - Phospholipid degradation is induced by heat in alpha-tocopherol-enriched eggs. 16822207 - Effects of paecilomyces tenuipes cultivated in egg yolk on lipid metabolism in rats on ... 22729657 - Isotopic reconstruction of human diet and animal husbandry practices during the classic... 18759757 - Self-reported dietary intake of omega-3 fatty acids and association with bone and lower... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Fertility and sterility Volume: 41 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1984 Mar |
Date Detail:
|
Created Date: 1984-04-26 Completed Date: 1984-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 455-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cervix Mucus / physiology Contraceptive Agents, Female / pharmacology* Female Humans Imidazoles / pharmacology* Macaca Male Sperm Motility / drug effects Spermatocidal Agents / pharmacology Spermatozoa / drug effects Vaginal Creams, Foams, and Jellies / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptive Agents, Female; 0/Imidazoles; 0/Spermatocidal Agents; 0/Vaginal Creams, Foams, and Jellies; 86996-65-8/1-(2-(2,4-dichlorobenzyloxy)-n-octyl)imidazole oxalate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A review of 357 bilateral vasectomies for male sterilization.
Next Document: Effect of variable concentration of serum on mouse embryo development.