| Evaluation of in vivo antineoplastic effects of rapamycin in patients with chemotherapy-refractory AML. | |
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MedLine Citation:
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PMID: 19892307 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The mammalian target of rapamycin (mTOR) has recently been identified as a potential target in acute myeloid leukemia (AML). METHODS: We treated 5 patients with chemotherapy-refractory AML with the mTOR-inhibitor rapamycin at 2mg per os daily for 14 days, with dose adjustment allowed to reach a target serum rapamycin concentration of 10-20 ng/mL. Four of five patients received additional hydroxyurea at constant dose during treatment with rapamycin. RESULTS: Two patients achieved a leukocyte response, in one of them, a prolonged response was seen. In the other patients, blast counts remained stable or increased during rapamycin therapy. We did not observe severe hematologic or non-hematologic side effects of rapamycin. CONCLUSION: Rapamycin at 2mg per day acts mildly cytoreductive in a subgroup of patients with refractory AML. Higher doses and drug combinations may be required to obtain long lasting anti-leukemic effects in these patients. |
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Authors:
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Alexandra Boehm; Matthias Mayerhofer; Susanne Herndlhofer; Paul Knoebl; Christian Sillaber; Wolfgang R Sperr; Ulrich Jaeger; Peter Valent |
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Publication Detail:
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Type: Journal Article Date: 2009-10-07 |
Journal Detail:
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Title: European journal of internal medicine Volume: 20 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 775-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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