| Evaluation of the impact of intraobserver variability on endometrial dating and the diagnosis of luteal phase defects. | |
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MedLine Citation:
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PMID: 8405519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the magnitude of intraobserver variation in dating endometrial biopsies and its impact on clinical management. DESIGN: Blinded histopathologic interpretation of endometrial biopsy specimens 1 year apart by five pathologists. SETTING: Large military tertiary care center. PATIENTS: Endometrial biopsy specimens from 51 patients undergoing evaluation for potential luteal phase defects. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Calculation of the magnitude of the individual and overall intraobserver variation in endometrial dating for the five pathologists and estimation of its potential impact on clinical management. RESULTS: The intraobserver variation was 0.69 +/- 0.05 days (means +/- SE). There was no significant difference in the magnitude of the variation for 1-day or 2-day dating ranges. The theoretical probability of altering clinical management by having the same pathologist redate a given specimen ranged from 15% to 28%. CONCLUSION: Histologic dating of endometrial biopsies is subject to a small but highly clinically significant intraobserver variability that may have a major impact on clinical management. |
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Authors:
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R T Scott; R R Snyder; J W Bagnall; K D Reed; C F Adair; S D Hensley |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 60 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-15 Completed Date: 1993-11-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 652-7 Citation Subset: IM |
Affiliation:
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Wilford Hall Medical Center, Lackland Air Force Base, Texas. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Endometrium / pathology* Female Humans Luteal Phase* Observer Variation* Probability Time Factors Uterine Diseases / pathology*, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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