| Evaluation of immunomodulatory activity of methanolic extract of Piper betel. | |
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MedLine Citation:
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PMID: 18476879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many of the disorders today are based on the imbalances of immunological processes. This necessitates the search for newer and safer immunomodulators. Thus, the objective of the present study was to explore the immunomodulatory activity of the methanolic extract of Piper betel L. (MPb) (Family: Piperaceae). The MPb consists of mixture of phenols, flavonoids, tannins and polysaccharides. Both in vitro as well as in vivo evaluation was carried out. The effects of MPb on lymphocyte proliferation, interferon-gamma receptors and the production of nitric oxide were measured in vitro. Further, the extract at different dose levels was studied in vivo for the humoral and cellular immune responses on mice immunized with sheep red blood cells. P. betel significantly suppressed phytohaemagglutinin stimulated peripheral blood lymphocyte proliferation in a dose-dependent manner. The decrease in antibody titre and increased suppression of inflammation suggests possible immunosuppressive effect of extract on cellular and humoral response in mice. Thus, the MPb could be explored extensively as a therapeutic agent to treat various immune disorders including autoimmune disorders. |
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Authors:
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D G Kanjwani; T P Marathe; S V Chiplunkar; S S Sathaye |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 67 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-14 Completed Date: 2008-06-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 589-93 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Science and Technology, University Institute of Chemical Technology, Matunga, Mumbai, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Antibodies / blood Cell Proliferation Cells, Cultured Dose-Response Relationship, Immunologic Erythrocytes / immunology Female Humans Hypersensitivity, Delayed / blood, immunology, metabolism Immunization Immunologic Factors / administration & dosage, pharmacology* Interferon-gamma Lymphocyte Activation / drug effects Lymphocytes / drug effects*, immunology, metabolism Male Methanol Mice Neutrophils / drug effects, immunology, metabolism Nitric Oxide / metabolism Piperaceae / immunology* Plant Extracts / administration & dosage, immunology*, pharmacology Plant Leaves / immunology Receptors, Interferon Sheep |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Immunologic Factors; 0/Plant Extracts; 0/Receptors, Interferon; 10102-43-9/Nitric Oxide; 67-56-1/Methanol; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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