Document Detail


Evaluation of ifenprodil efficacy on exercise-induced tissue ischemia in stage II arteriopathy by measurement of transcutaneous oxygen tension during a standard treadmill test: double-blind study of injectable ifenprodil versus placebo.
MedLine Citation:
PMID:  8328683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurement of transcutaneous oxygen tension (TcPO2) is a noninvasive and easily reproducible method for objectifying and quantifying exercise ischemia in patients with stage II occlusive arterial disease. This technique is also used at rest to evaluate the therapeutic effect of vasoactive treatments. To objectively assess the effectiveness of a vasoactive treatment on the conditions of tissue perfusion, a randomized double-blind study of ifenprodil tartrate versus placebo was performed in 20 patients, whose TcPO2 was continuously measured while they walked on a treadmill. Patients treated with ifenprodil improved significantly as compared with the placebo group, for both the half-hypoxia area, representing the overall evolution of the tissue ischemia (+34.9% and -16.0%, respectively, p = 0.01), and the half-hypoxia recovery time, estimating the postexercise recovery time (+30.2% and -3.6%, respectively, p < 0.05). This study confirms that the continuous measurement of TcPO2 during the recovery phase after exercise represents an objective method for the evaluation and follow-up of patients with stage II intermittent claudication. The results enabled the objective assessment of ifenprodil efficacy on the evolution of tissue hypoxia.
Authors:
P Caillard; X Mouren; O Bailliart; M Cloarec
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  44     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  552-60     Citation Subset:  IM    
Affiliation:
Policlinique médicale, Hôpital Tenon, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Blood Gas Monitoring, Transcutaneous
Double-Blind Method
Female
Humans
Injections, Intramuscular
Ischemia / blood,  drug therapy*
Leg / blood supply*
Male
Middle Aged
Oxygen / blood*
Physical Exertion*
Piperidines / administration & dosage*
Vasodilator Agents / administration & dosage*
Chemical
Reg. No./Substance:
0/Piperidines; 0/Vasodilator Agents; 23210-56-2/ifenprodil; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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