Document Detail


Evaluation of ibuprofen dimethyl aminoethanol octyl bromide and related active metabolites in biological samples.
MedLine Citation:
PMID:  2383307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AF 150 is ibuprofen dimethyl aminoethanol octyl bromide, endowed with antibacterial and antiinflammatory activities. An indirect HPLC analytical method for AF 150 with UV detection, to be used for pharmacokinetic studies, has been validated in terms of linearity, reproducibility, specificity and sensitivity. Using this method the bioavailability of AF 150 and its active metabolite ibuprofen was investigated following parenteral administration and topical application.
Authors:
A Marzo; A Reiner; N Monti; M Ripamonti; C Lucarelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  40     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  614-7     Citation Subset:  IM    
Affiliation:
Real srl, Villaguardia, Como, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Chromatography, High Pressure Liquid
Female
Ibuprofen / analogs & derivatives*,  analysis*,  blood,  pharmacokinetics
Kidney / analysis
Liver / analysis
Rats
Rats, Inbred Strains
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
113168-14-2/ibuprofen dimethyl aminoethanol octyl; 15687-27-1/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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