Document Detail

Evaluation of hypothalamic-pituitary-adrenal axis in premature infants treated with dexamethasone.
MedLine Citation:
PMID:  8989477     Owner:  NLM     Status:  MEDLINE    
Results of a national survey of the current use of steroids in newborns in 1993 showed that 95% of the neonatologists in the United States have used dexamethasone for neonates at risk for chronic lung disease. Dexamethasone therapy for a period of a week or longer is associated with suppression of the hypothalamic-pituitary-adrenal axis (HPAA) in a substantial number of premature infants. A review of our current understanding of the biochemical tests evaluating HPAA function in premature infants and suggested guidelines for HPAA evaluation and management following dexamethasone therapy are presented.
A L Alkalay; A H Klein; R A Nagel; J J Pomerance
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  13     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-25     Completed Date:  1997-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Division of Neonatology, Ahmanson Pediatric Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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MeSH Terms
Adrenocorticotropic Hormone / diagnostic use
Corticotropin-Releasing Hormone / diagnostic use
Dexamethasone / adverse effects*,  therapeutic use
Glucocorticoids / adverse effects*,  therapeutic use
Hypothalamo-Hypophyseal System / drug effects*
Infant, Newborn
Infant, Premature / physiology
Infant, Premature, Diseases / prevention & control*
Metyrapone / diagnostic use
Pituitary-Adrenal System / drug effects*
Respiratory Distress Syndrome, Newborn / prevention & control*
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone; 54-36-4/Metyrapone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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