| Evaluation of hydrogel-based controlled-release niacin tablets. | |
| | |
MedLine Citation:
|
PMID: 9876611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Matrix-based controlled-release niacin tablets were formulated using guar gum. The effect on the in vitro dissolution profile was examined using variable guar gum content in the formulation. It was observed that the dissolution profile declined with the increase in the guar gum content in the tablet. The in vitro dissolution profile was also observed under different pH conditions and there was no marked change. The moisture content of granules also did not cause any considerable change in dissolution profile. Three different strength Niacin controlled-release tablets, including 500 mg, were prepared and it was found that applying the same variables of different guar gum content and moisture content of granules resulted in a very insignificant change in the in vitro dissolution profile. The experimental formulation compared well with commercial products and met the proposed standards for controlled-release products. |
| | |
Authors:
|
P Khullar; R K Khar; S P Agarwal |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
|
Title: Drug development and industrial pharmacy Volume: 24 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 1998 May |
Date Detail:
|
Created Date: 1999-02-01 Completed Date: 1999-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 479-83 Citation Subset: IM |
Affiliation:
|
Dabur Research Foundation, Ghaziabad, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemistry, Pharmaceutical Delayed-Action Preparations Drug Stability Galactans Humans Hydrogels Hydrogen-Ion Concentration Mannans Niacin / administration & dosage*, chemistry Plant Gums Tablets Vehicles Viscosity Water |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 0/Galactans; 0/Hydrogels; 0/Mannans; 0/Plant Gums; 0/Tablets; 0/Vehicles; 59-67-6/Niacin; 7732-18-5/Water; 9000-30-0/guar gum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Product development studies on the tablet formulation of ibuprofen to improve bioavailability.
Next Document: Identification of the mebendazole polymorphic form present in raw materials and tablets available in...