Document Detail

Evaluation of human diaphragm contractility using mouth pressure twitches.
MedLine Citation:
PMID:  1586048     Owner:  NLM     Status:  MEDLINE    
Mouth (PmT), esophageal (PesT), and transdiaphragmatic pressure twitches (PdiT) in response to single supramaximal bilateral phrenic nerve shocks were recorded during relaxation between total lung capacity (TLC) and functional residual capacity (FRC) in five normal volunteers. The PmT versus PesT or PmT versus PdiT relationships, which were linearly correlated (all r greater than 0.76), were not affected by diaphragm fatigue and were reproducible on repeated determinations over a period exceeding 1 yr. The PmT versus lung volume relationship was also linear (all r greater than 0.72) and reproducible, and its changes following diaphragm fatigue reliably reflected the changes in diaphragm contractility. We conclude that PmT is a reliable measure of diaphragm pressure-generating capacity in normal individuals and has the potential of providing similar information in patients.
S Yan; A P Gauthier; T Similowski; P T Macklem; F Bellemare
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  145     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-12     Completed Date:  1992-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1064-9     Citation Subset:  AIM; IM    
Meakins-Christie Laboratories, McGill University Clinic, Royal Victoria Hospital, Quebec, Canada.
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MeSH Terms
Diaphragm / physiology*
Electric Stimulation
Functional Residual Capacity / physiology
Muscle Contraction / physiology*
Phrenic Nerve / physiology
Respiratory Insufficiency / diagnosis
Total Lung Capacity / physiology
Transducers, Pressure

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