Document Detail

Evaluation of hormone replacement therapy which may have an adrenomedullin-mediated protective effect on cardiovascular disorders.
MedLine Citation:
PMID:  17607091     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: This study aimed to determine whether there is an adrenomedullin (AM)-mediated protective effect of postmenopausal estrogen/progestin therapy (HRT) against cardiovascular disorders. METHODS: A total of 22 post-menopausal women without hysterectomy undergoing postmenopausal symptoms (aged 43-52) were treated with conjugated equine estrogen (0.625 mg/die) plus medroxyprogesterone acetate (2.5 mg/die) for six months. The flow velocity of the right middle cerebral artery [measured as resistance index (RI) and pulsatility index (PI)], plasma levels of adrenomedullin and endothelin- 1 (ET-1), mean baseline ratio of AM to ET-1, and lipid profiles were assessed before and after HRT. RESULTS: A statistically significant difference was found for triglycerides, total cholesterol, AM/ET-1 ratio and right middle cerebral artery PI (p<0.05), without any significant differences in HDL, LDL, AM, ET-1, systolic blood pressure, diastolic blood pressure, a right middle cerebral artery RI (p>0.05) between pre- and post- HRT. CONCLUSIONS: Adrenomedullin may be added to other vasoactive peptides as a new potential candidate for HRT-mediated vascular protection. The ratio of AM/ET-1 vs AM or ET-1 alone may be a useful biological marker of this protection.
Merih Bayram; Orhan Bayram; M Yasemin Karadeniz Bilgili; Osman Caglayan; Mustafa N Ilhan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aging clinical and experimental research     Volume:  19     ISSN:  1594-0667     ISO Abbreviation:  Aging Clin Exp Res     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101132995     Medline TA:  Aging Clin Exp Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  224-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
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MeSH Terms
Adrenomedullin / blood,  physiology*
Blood Pressure
Cardiovascular Diseases / prevention & control*
Cerebrovascular Circulation
Endothelin-1 / blood
Estrogen Replacement Therapy*
Lipids / blood
Middle Aged
Reg. No./Substance:
0/Endothelin-1; 0/Lipids; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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