Document Detail

Evaluation of hepatic functions and biliary dynamics in patients with liver cirrhosis by quantitative scintigraphy.
MedLine Citation:
PMID:  14696409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Aim of the study is to determine the changes in hepatocyte and gallbladder motor functions, and biliary dynamics in patients with liver cirrhosis. METHODOLOGY: The study group consisted of 17 patients with liver cirrhosis (12 males, 5 females) who were diagnosed by clinical, laboratory and histopathologic findings. Control group consisted of 20 healthy persons (14 males, 6 females). Quantitative hepatobiliary scintigraphy was performed by using Tc99m-Mebrofenin i.v. and dynamic images were obtained and evaluated quantitatively by computer. Maximum excretion time of radiodiagnostic agent by liver (Tmax) and half excretion time of radio-diagnostic agent from liver (T 1/2), gallbladder filling time, gallbladder ejection fraction and the transit time of bile to duodenum were determined. RESULTS: Mean values of Tmax was 25.76 vs. 12.40 min, T 1/2 was 37.55 vs. 23.15 min, gallbladder filling time was 53.35 vs. 30.57 min, and transit time of bile to duodenum was 39.88 vs. 25.00 min in the patients and control group, respectively. These values increased significantly in the patient group (p < 0.05) compared to controls. Mean gallbladder ejection fraction was 37.55% in the patient group and 41.84% in the control group without any statistical significance (p > 0.05). The incidence of gallbladder stone was 29.41% in the cirrhosis group and 5% in the control group (p < 0.05). CONCLUSIONS: The quantitative hepatobiliary scintigraphy is a simple and reliable method in evaluation of hepatic functions and biliary dynamics in cirrhotic patients. Although the incidence of gallbladder stone is significantly increased in cirrhotic patients, it seems that a stone in the gallbladder does not affect the gallbladder motor functions.
Mehmet Koruk; Sinasi Ozkiliç; M Cemil Savas; Zeki Celen; Abdurrahman Kadayifçi; Canan Ozkiliç
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  50     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-06-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1803-5     Citation Subset:  IM    
Department of Internal Medicine, University of Gaziantep, Gaziantep, Turkey.
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MeSH Terms
Bile / physiology
Biliary Dyskinesia / pathology,  radionuclide imaging*
Duodenum / pathology,  radionuclide imaging
Gallbladder / pathology,  radionuclide imaging
Gallbladder Emptying / physiology
Gallstones / pathology,  radionuclide imaging
Image Processing, Computer-Assisted*
Liver / pathology,  radionuclide imaging
Liver Cirrhosis / etiology,  pathology,  radionuclide imaging*
Liver Function Tests*
Metabolic Clearance Rate / physiology
Middle Aged
Organotechnetium Compounds / diagnostic use,  pharmacokinetics
Radionuclide Imaging*
Reference Values
Technetium / diagnostic use,  pharmacokinetics
Reg. No./Substance:
0/Organotechnetium Compounds; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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