Document Detail

Evaluation of healing processes of intraosseous defects with and without guided bone regeneration and platelet rich plasma. An animal study.
MedLine Citation:
PMID:  22999915     Owner:  NLM     Status:  Publisher    
BACKGROUND: In most cases, the natural healing of intrabony defects only leads to restoration of tissue continuity without differentiation and function. However, repair is not regarded to be an optimal treatment method, as confirmed in many clinical cases. Thus it is important to choose a surgical procedure which makes it possible to achieve restitution ad integrum of the bone structure. The choice of the GBR technique is crucial, in terms of the clinical conditions and limitations resulting from the use of a particular material. OBJECTIVE: The objective of this study has been the analysis of effectiveness of selected surgical treatment techniques of intrabony defects in rabbits. MATERIALS AND METHODS: Research was conducted on 36 white rabbits. The operation technique was a criterion of division into 3 groups: BG/BOC (Bio-Oss Collagen(®)+Bio-Gide Perio(®)), BOC/PRP (Bio-Oss Collagen(®)+PRP), C (control group). Qualitative and quantitative histopathological evaluation was carried out after 1, 3, 6 and 12 months. RESULTS: The highest value of the bone surface area 31.9% (SD 1.8) was achieved in BOC/BG group three months after the implantation, while the lowest was revealed in C - group - 12.5% (SD 1.32) one month following the procedure. CONCLUSIONS: Upon quantitative histological assessment, the bone tissue presented the most intensive osteogenesis within one month from the application of BOC/PRP, whereas this was observed after the application of BOC/BG in later stages. The application of two regenerative methods influenced the rate, quality and overall treatment of intraosseus defects.
Marzena Dominiak; Katarzyna Lysiak-Drwal; Leszek Solski; Bogusława Zywicka; Zbigniew Rybak; Tomasz Gedrange
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-4
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  -     ISSN:  1618-0402     ISO Abbreviation:  Ann. Anat.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier GmbH.
Department of Oral Surgery, Silesian Piast Medical University, Wrocław, Poland. Electronic address:
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