Document Detail

Evaluation of hawthorn extract on immunomodulatory biomarkers in a pressure overload model of heart failure.
MedLine Citation:
PMID:  18049426     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hawthorn extract (Crataegeus sp.) a botanical complementary and alternative medicine is often used to treat heart failure. The mechanism(s) by which hawthorn extract may treat heart failure is unknown but may include, theoretically, immunological effects. Therefore, the purpose of this study is to determine the effect of hawthorn extract on the immunomodulatory response in a pressure overload model of heart failure. MATERIAL/METHODS: A total of 62 male Sprague-Dawley rats were randomized to either aortic constriction + vehicle (AC; n=15), aortic constriction + hawthorn 1.3 mg/kg (HL, n=17), aortic constriction + hawthorn 13 mg/kg (HM, n=15), or aortic constriction + hawthorn 130 mg/kg (HH, n=15). Six months after surgical procedure animals were sacrificed and plasma samples obtained for the measurement of the following immunomodulatory markers: interleukin (IL) IL-1ss, IL-2, IL-6, IL-10; and leptin. RESULTS: The mortality rate following 6 months of aortic constriction was 40% in the AC group compared to 41%, 60%, and 53% for the HL, HM, and HH groups respectively (P>0.05 compared to AC). Aortic constriction produced a similar increase in the left ventricle/body weight ratio for all groups. Hawthorn extract had no effect on the immunomodulatory markers measured in this study, although there appeared to be a trend suggesting suppression of IL-2 plasma concentrations. CONCLUSIONS: In this animal model of heart failure, hawthorn extract failed to significantly affect the immunomodulatory response characterized after 6 months of pressure overload at a time when approximately 50% mortality was exhibited. Mechanisms other than immunological may better define hawthorn's effect in treating heart failure.
Barry E Bleske; Issam Zineh; Hyun Seok Hwang; Gregory J Welder; Michael M J Ghannam; Marvin O Boluyt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  13     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  BR255-8     Citation Subset:  IM    
College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA.
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MeSH Terms
Aorta / physiopathology
Biological Markers / metabolism
Constriction, Pathologic / complications
Crataegus / chemistry*
Cytokines / metabolism
Disease Models, Animal
Heart Failure / drug therapy,  etiology,  immunology*
Plant Extracts / therapeutic use
Random Allocation
Rats, Sprague-Dawley
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Plant Extracts

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