| Evaluation of group homogeneity during acupuncture stimulation in fMRI studies. | |
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MedLine Citation:
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PMID: 20677254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the extent of individual differences of functional MRI (fMRI) signal changes induced by acupuncture stimulation. MATERIALS AND METHODS: Acupuncture at ST36 and checkerboard stimulation was applied to 16 subjects. We calculated the mean distance using beta values in a generalized linear model (GLM) analysis and employed it to study the group homogeneity by detecting the outliers. RESULTS: A more significant individual difference was presented in acupuncture stimulation compared with visual stimulation through evaluation of the mean distance. From the group results, we found that the activations were more significant in the homogeneous group results. Combining the behavior and fMRI results, there was no direct correlation between deqi index and mean distance in acupuncture stimulation. The deqi index of the outlier was in the normal range and did not differ significantly from others. CONCLUSION: Traditional group results without removing outliers were not sensitive enough to detect the real acupuncture effect. We suggest that individual difference should be taken into consideration for future acupuncture studies. Also, group analysis paralleled with individual analysis is critical for a full understanding of acupuncture effects. |
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Authors:
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Jinbo Sun; Wei Qin; Minghao Dong; Kai Yuan; Jixin Liu; Peng Liu; Yi Zhang; Karen M von Deneen; Jie Tian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 298-305 Citation Subset: IM |
Copyright Information:
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2010 Wiley-Liss, Inc. |
Affiliation:
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Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acupuncture
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methods* Acupuncture Points Acupuncture Therapy Adult Brain / physiology Brain Mapping / methods* Computer Simulation Female Humans Linear Models Magnetic Resonance Imaging / methods* Male Models, Statistical Photic Stimulation |
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