Document Detail


Evaluation of glucose-6-phosphate dehydrogenase deficiency without hemolysis in icteric newborns at Mazandaran province, Iran.
MedLine Citation:
PMID:  18817276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was carried out with the aim of evaluating the prevalence of G6PD deficiency, the prevalence of hemolysis with enzyme deficiency and determining the severity of icterus in the hospitalized newborns in our hospital. This prospective descriptive study has been conducted on 1018 icteric newborns admitted to the Bo-Ali Hospital from 2004 to 2007. The dataset included: age, sex, total and direct bilirubin, hemoglobin, reticulocyte count, blood group and Rh of mother and newborn, direct Coombs, G6PD level and the type of treatment. All data was analyzed by using statistical method. From 1018 neonates, 138 neonates (13.6%) were found to have G6PD deficiency. The male to female ratio was 3 to 1 (104 male and 34 female neonates). From 138 neonates with G6PD deficiency, hemolysis was seen in 15 neonates (10.9%) and the rate of G6PD deficiency with hemolysis was 1.6%. Out of 138 patients with G6PD deficiency, 2 patients (0.2%) had blood exchange transfusion. In this study the prevalence of G6PD deficiency in icteric newborns was considerably high and most of them were non hemolytic, so we recommend G6PD test as a screening program for every newborn at the time of delivery.
Authors:
Amir Hossein Ahmadi; Zeynab Ghazizadeh
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  11     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-09-26     Completed Date:  2008-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  1394-7     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
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MeSH Terms
Descriptor/Qualifier:
Cross-Sectional Studies
Female
Glucosephosphate Dehydrogenase Deficiency / blood*,  epidemiology
Hemolysis*
Humans
Infant, Newborn
Iran / epidemiology
Jaundice* / enzymology,  etiology
Male
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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