| Evaluation of glomerular filtration rate by use of dynamic computed tomography and Patlak analysis in clinically normal cats. | |
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MedLine Citation:
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PMID: 21879988 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective-To obtain quantitative variables of the abdominal aorta and both kidneys on the basis of time-attenuation curves (TACs) and to measure glomerular filtration rate (GFR) for each kidney and the global GFR in clinically normal cats by use of dynamic computed tomography (CT) and Patlak analysis. Animals-9 healthy cats. Procedures-All the cats were anesthetized with propofol. Anesthesia was maintained by administration of isoflurane, and CT examination was performed in the anesthetized cats. The TACs and renal volume were measured by use of the baseline precontrast and single-slice dynamic scans. The CT-GFR of each kidney and the global CT-GFRs were calculated via Patlak plot analysis. Results-CT-GFR results from 7 cats were valid. Peak aortic enhancement was detected between 9.0 and 14.0 seconds after iohexol injection, and the initial peak time of renal parenchymal enhancement was 15 to 24 seconds after iohexol injection. Mean ± SD global GFR was 2.06 ± 0.62 mL/min/kg. Mean ± SD CT-GFR of the right and left kidneys was 0.97 ± 0.32 mL/min/kg and 1.05 ± 0.31 mL/min/kg, respectively. Conclusions and Clinical Relevance-The CT-GFR method can be rapidly and conveniently performed in clinically normal cats. This combined structural-functional approach provided physiologic and morphological information on the kidneys of cats. |
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Authors:
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Jinhwa Chang; Sejoon Ahn; Sooyoung Choi; Heechun Lee; Dongwoo Chang; Hojung Choi; Youngwon Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of veterinary research Volume: 72 ISSN: 1943-5681 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 1276-82 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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