| Evaluation of global left ventricular function and mechanical dyssynchrony in patients with an asymptomatic left bundle branch block: a real-time 3D echocardiography study. | |
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MedLine Citation:
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PMID: 17446139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A left bundle branch block (LBBB) affects both global left ventricular (LV) function and mechanical dyssynchrony. The aim was to evaluate global LV function and mechanical dyssynchrony with real-time 3D echocardiography (RT3DE), in asymptomatic LBBB patients, healthy volunteers and patients with symptomatic heart failure (HF) and a LBBB. Furthermore, the relation between presence or absence of symptoms of HF and mechanical dyssynchrony was investigated. METHODS: RT3DE was performed in 61 consecutive patients: 16 healthy volunteers, 22 patients with an asymptomatic LBBB and 23 patients with symptomatic HF and a LBBB. Global LV function and the systolic dyssynchrony index (SDI) were measured. RESULTS: In healthy volunteers, mean LV ejection fraction was 54 +/- 5%, in asymptomatic LBBB patients 50 +/- 9%, and in HF patients 29 +/- 9%. SDI was 5.6 +/- 3.6%, 7.3 +/- 3.2% and 12.8 +/- 4.8% for healthy volunteers, asymptomatic LBBB patients and HF patients respectively. SDI differed significantly between HF patients and both other groups. A cut-off value for SDI for presence of symptoms of HF was 10.8%. CONCLUSION: Asymptomatic LBBB patients have more depressed global LV function than healthy volunteers have; patients with symptoms of HF and a LBBB have severe global LV dysfunction. Asymptomatic LBBB patients have an intermediate mechanical dyssynchrony; HF patients with a LBBB have the most severe mechanical dyssynchrony. A substantial amount of mechanical dyssynchrony might be accompanied by the presence of symptoms of HF. |
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Authors:
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Jeroen van Dijk; Pieter A Dijkmans; Marco J W Götte; Marieke D Spreeuwenberg; Cees A Visser; Otto Kamp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology Volume: 9 ISSN: 1532-2114 ISO Abbreviation: Eur J Echocardiogr Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-02-12 Completed Date: 2008-06-03 Revised Date: 2008-07-29 |
Medline Journal Info:
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Nlm Unique ID: 100890618 Medline TA: Eur J Echocardiogr Country: England |
Other Details:
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Languages: eng Pagination: 40-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology ZH 6D 120, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. jeroen.vandijk@vumc.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Bundle-Branch Block / physiopathology*, ultrasonography* Case-Control Studies Echocardiography, Three-Dimensional* Female Heart Conduction System / physiopathology* Humans Male Middle Aged ROC Curve Reproducibility of Results Ventricular Dysfunction, Left / physiopathology*, ultrasonography* |
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