| Evaluation of gingival crevicular fluid adrenomedullin and human neutrophil peptide 1-3 levels of patients with different periodontal diseases. | |
| | |
MedLine Citation:
|
PMID: 20151808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Antimicrobial peptides participating in the innate host response are important contributors for maintaining the balance between health and disease. The aim of the present study is to investigate the levels of gingival crevicular fluid (GCF) adrenomedullin and human neutrophil peptides 1 through 3 (HNP1-3) in patients with different periodontal diseases. METHODS: A total of 77 subjects, including 20 patients with chronic periodontitis, 18 patients with generalized aggressive periodontitis, 20 patients with gingivitis, and 19 healthy subjects, were included in the present study. The probing depth, clinical attachment level, plaque index, and papilla bleeding index were assessed in all study subjects. GCF samples were analyzed for evaluating adrenomedullin and HNP1-3 levels by enzyme-linked immunosorbent assay. RESULTS: The present study demonstrated that the periodontitis groups had a significantly higher total amount of GCF adrenomedullin compared to the gingivitis and healthy control groups after adjusting for age and gender (P <0.05). Additionally, GCF adrenomedullin levels were positively correlated with clinical periodontal parameters of sampling sites (P <0.05). The total amount of GCF HNP1-3 was not different among the study groups, and there was no correlation between the total amount of GCF HNP1-3 and clinical periodontal parameters (P >0.05). CONCLUSIONS: Our results suggest a defensive role for adrenomedullin during the host response in periodontal disease. Additionally, the lack of the HNP1-3 antimicrobial peptide might point to the deficiency of one of the protective mechanisms for periodontal tissues. |
| | |
Authors:
|
Oya T?rko?lu; G?lnur Emingil; Necil K?t?k??ler; G?l Atilla |
Related Documents
:
|
6331058 - Low superoxide levels in blood phagocytic cells in down's syndrome. 6375238 - Glycogen in leukocytes from patients with hepatic encephalopathy. 7186088 - Neutrophil function in advanced hodgkin's disease: effect of therapy. 11073768 - Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infecti... 21777528 - Factors predicting the recurrence of spontaneous bacterial peritonitis in patients with... 10762518 - Detection of ventricular enlargement in patients at the earliest clinical stage of ms. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of periodontology Volume: 81 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-15 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
|
Languages: eng Pagination: 284-91 Citation Subset: D; IM |
Affiliation:
|
Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey. oya_t@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenomedullin
/
immunology,
metabolism* Adult Case-Control Studies Gingival Crevicular Fluid / immunology, metabolism* Gingivitis / immunology, metabolism* Humans Male Middle Aged Periodontitis / immunology, metabolism* Reference Values Young Adult alpha-Defensins / immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/alpha-Defensins; 0/human neutrophil peptide 1; 0/human neutrophil peptide 2; 0/human neutrophil peptide 3; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Salivary and gingival crevicular fluid melatonin in periodontal health and disease.
Next Document: Antimicrobial susceptibility of moxifloxacin against gram-negative enteric rods from colombian patie...