Document Detail

Evaluation of gestrinone after surgery in treatment of endometriosis.
MedLine Citation:
PMID:  9127134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The clinical and histological efficacy of gestrinone in the treatment of endometriosis was evaluated. METHODS: A prospective study was performed with longitudinal follow-up of 4 years duration (minimum) for each patient. Twenty-five cases of endometriosis were treated with gestrinone (as a drug of choice or associated with other local surgical treatment) during 6 months. RESULTS: The total or partial response to pain was induced with treatment in 19 of the 20 cases (95%), and posttreatment pregnancies were induced in 3 of the 9 cases of infertility (33.3%). The global clinical efficacy was as follows: none (n = 5, 20%), poor (n = 2, 8%), moderate (n = 2, 8%), good (n = 3, 12%) and excellent (n = 13, 52%). The pretreatment American Fertility Society score was 23.1 +/- 3.8 points (2-58) and that after treatment (re-examination) 7.8 +/- 3.7 points (0-52), p < 0.01. Global histological efficacy (n = 17) results were as follows: none (23.6%), poor (0%), moderate (5.8%), good (35.3%) and excellent (35.3%). CONCLUSIONS: Gestrinone is presented as a drug with an efficacy comparable to other pharmacological agents currently available in the medical treatment of endometriosis. Adequate posology and acceptable effectiveness were also observed.
A Nieto; C Tacuri; M Serra; J Keller; J Cortés-Prieto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  43     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1997  
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  192-4     Citation Subset:  IM    
Hospital Universitario Principe de Asturias, Facultad de Medicina, Departamento de Especialidades Médicas, Universidad de Alcalá, Madrid, Spain.
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MeSH Terms
Abdominal Pain / therapy
Combined Modality Therapy
Endometriosis / drug therapy*,  surgery*
Gestrinone / therapeutic use*
Progesterone Congeners / therapeutic use*
Prospective Studies
Reg. No./Substance:
0/Progesterone Congeners; 16320-04-0/Gestrinone

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