Document Detail

Evaluation of the genotoxicity of some natural food colours using bacterial assays.
MedLine Citation:
PMID:  7022199     Owner:  NLM     Status:  MEDLINE    
The genotoxicity of 5 natural food colours currently permitted within the European Economic Community has been studied. Ability to induce DNA damage was investigated by the use of a recently-developed E. coli rec assay. The induction of reverse mutations in E.coli WP2 trp uvrA and S.typhimurium TA1538 his rfa uvrB was detected in fluctuation assays. Both types of assays were conducted with and without metabolic activation using caecal extracts and liver microsomes from rats. Results obtained in these systems suggest that none of the colourings screened induced detectable genotoxicity.
R B Haveland-Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  91     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1981 Jul-Sep
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
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MeSH Terms
Cecum / metabolism
Escherichia coli / drug effects
Food Coloring Agents*
Mutagenicity Tests
Salmonella typhimurium / drug effects
Reg. No./Substance:
0/Food Coloring Agents; 0/Mutagens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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