Document Detail


Evaluation of genotoxic effects of semicarbazide on cultured human lymphocytes and rat bone marrow.
MedLine Citation:
PMID:  19819287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Semicarbazide (SEM) belongs to the hydrazine family of chemicals, some members of which are known to possess carcinogenic potential. Information on the potential hazard of SEM itself is incomplete and the possibility that it is genotoxic cannot be ruled out. SEM is widely used as a residue marker for the banned veterinary drug nitrofurazone. Also, it occurs as a break-down product of azodicarbonamide (ADC), a chemical used as a flour treatment. Furthermore, it may form as a reaction product of hypochlorite action on food additives. In the present study, we investigated the possible genotoxic effects of SEM with respect to the following cytogenetic end-points: (1) in vitro micronucleus (MN) formation and sister-chromatid exchange (SCE) induction in human lymphocytes and (2) in vivo micronucleus induction on rat bone marrow polychromatic erythrocytes (PCEs). Comparing MN and SCE frequencies on control and examined concentrations (0.5, 2.5, 5, 10 and 20 microg ml(-1)) did not reveal statistically significant differences except, marginally, the highest concentration (20 microg ml(-1)) in SCE analysis. On the other hand, oral administration of 50, 100 and 150 mg kg(-1) b.w. of SEM showed a statistically significant effect in MN frequencies on Wistar rats' bone marrow PCEs, with no dose-response pattern.
Authors:
Dimitris Vlastos; Hariklia Moshou; Klimentini Epeoglou
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2009-10-09
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Environmental and Natural Resources Management, University of Ioannina, Agrinio, Greece. dvlastos@cc.uoi.gr
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Alkylating / toxicity
Bone Marrow Cells / drug effects*
Cells, Cultured
Chromosomes / drug effects,  ultrastructure
Cyclophosphamide / toxicity
Erythrocytes / drug effects,  ultrastructure
Humans
Lymphocytes / drug effects*
Male
Micronucleus Tests
Mutagens / toxicity*
Rats
Rats, Wistar
Semicarbazides / toxicity*
Sister Chromatid Exchange / drug effects
Young Adult
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 0/Mutagens; 0/Semicarbazides; 50-18-0/Cyclophosphamide

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