Document Detail

Evaluation of genetic, common-litter, and within-litter effects on preweaning mortality in a birth cohort of puppies.
MedLine Citation:
PMID:  10490080     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine relative impact of genetic, common-litter, and within-litter factors on puppy mortality. ANIMALS: 2,622 Boxer puppies of 413 litters born during a 14-month period. PROCEDURE: For each puppy, pedigree was determined, and litter in which it was born was registered. Overall mortality and mortality per specific cause of death were analyzed by use of a model that included an additive genetic effect, common-litter effect, within-litter effect, and regression of mortality on inbreeding coefficient. Relative importance of the effects was determined from estimates of the variance in mortality explained by each factor. RESULTS: 22% of the puppies died before reaching 7 weeks old. Stillbirth was the most frequent cause of death, followed by infection. Most observed differences were attributable to within-litter factors, which explained 67% of the variance in death attributable to infection and < or = 96% of the variance in death attributable to asphyxia. Common-litter factors were more important than additive genetic factors. Variance attributed to common-litter factors ranged from 2% for cheiloschisis, palatoschisis, or cheilopalatoschisis to 30% for death attributable to infection, and variance attributed to additive genetic factors ranged from 0% for asphyxia to 14% for euthanatized because of white color. Inbreeding coefficient had a significant effect on death attributable to infection, which increased 0.26% for each percentage increase of inbreeding. CONCLUSIONS AND CLINICAL RELEVANCE: Additive genetic factors have less impact on preweaning mortality than common-litter factors, which in turn have less impact than within-litter factors. Mortality attributable to infection increases significantly with increases in inbreeding.
S van der Beek; A L Nielen; Y H Schukken; E W Brascamp
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  60     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-01     Completed Date:  1999-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1106-10     Citation Subset:  IM    
Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, The Netherlands.
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MeSH Terms
Animals, Newborn / genetics*,  physiology
Animals, Suckling / genetics*,  physiology
Bayes Theorem
Cohort Studies
Dog Diseases / genetics,  mortality*
Dogs / genetics*,  physiology
Fetal Death / epidemiology,  genetics,  veterinary
Likelihood Functions
Models, Biological*
Netherlands / epidemiology
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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