Document Detail

Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in mice.
MedLine Citation:
PMID:  15287075     Owner:  NLM     Status:  MEDLINE    
Portulaca oleracea is commonly used in Iranian folk medicine. The aqueous and ethanolic extracts were studied in mice for their ability to inhibit gastric lesions induced by HCl or absolute ethanol. In addition, their effects on gastric acid secretion were measured. Both extracts showed a dose-dependent reduction in severity of ulcers. The highest dose of extracts exerted similar activity to sucralfate. The oral and intraperitoneal administration of extracts reduced the gastric acidity in pylorus-ligated mice. These results suggest that Portulaca oleracea has gastroprotective action and validates its use in folk medicine for gastrointestinal diseases.
Gholamreza Karimi; Hossein Hosseinzadeh; Negin Ettehad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  18     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-08-02     Completed Date:  2004-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  484-7     Citation Subset:  IM    
Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashad, Iran.
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MeSH Terms
Anti-Ulcer Agents / administration & dosage,  pharmacology*,  therapeutic use
Dose-Response Relationship, Drug
Ethanol / diagnostic use
Hydrochloric Acid / diagnostic use
Medicine, Traditional
Mice, Inbred BALB C
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Plant Leaves
Stomach Ulcer / chemically induced,  prevention & control*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Plant Extracts; 64-17-5/Ethanol; 7647-01-0/Hydrochloric Acid

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