| Evaluation of the function of arteriolar opening by variability in microcirculatory blood flow following angiotensin II administration in rats. | |
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MedLine Citation:
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PMID: 21084747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We aimed to verify whether microcirculatory blood flow variability (MBFV) parameters calculated from beat-to-beat laser Doppler flowmetry (LDF) waveforms can be used instead of microcirculatory blood flow (MBF) as an index to discriminate different local microcirculatory regulation in terms of the opening condition of arteriolar openings (AO) at different sites. METHODS: Angiotensin II (Ang-II) was administered to nine healthy male rats. LDF probes were placed on their renal cortex and plantar palm. The pulse width (PW) and coefficient of variance of the flux (ϕ) for all the pulses within a data sequence was calculated to evaluate the AO's opening condition. RESULTS: Monitoring and prediction linear-regression analyses revealed significant positive ϕ-vs-μ (mean flux) and PW-vs-μ slopes at renal cortex for their changes relative to the baseline values. CONCLUSION: The present results suggest that these parameters calculated from the beat-to-beat LDF waveform could be useful for monitoring MBF by administering Ang-II. Moreover, possible time-domain causal relation between changes in μ and these parameters was revealed, which may allow the prediction of changes in MBF that occur 10-30 min thereafter. Deeper understanding of MBFV parameters could be useful in monitoring of progression of cardiovascular diseases and in predicting the efficacy of specific therapies. |
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Authors:
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Hsin Hsiu; Shih-Min Huang; Tse-Lin Hsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biorheology Volume: 47 ISSN: 1878-5034 ISO Abbreviation: Biorheology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-06-10 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 0372526 Medline TA: Biorheology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 239-53 Citation Subset: IM |
Affiliation:
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Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC. hhsiu@mail.ntust.edu.tw [corrected] |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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administration & dosage*,
pharmacology* Animals Arterioles / drug effects*, physiology* Blood Pressure / drug effects, physiology Male Microcirculation / drug effects*, physiology Pulse Rats Rats, Inbred WKY Time Factors |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
| Comments/Corrections | |
Erratum In:
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Biorheology. 2010;47(5-6):333 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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