| Evaluation of folate conjugated pegylated thermosensitive magnetic nanocomposites for tumor imaging and therapy. | |
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MedLine Citation:
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PMID: 20851578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Superparamagnetic iron oxide nanoparticles (SPIONs) have been receiving great attention lately in biomedical applications, such as in magnetic resonance imaging and drug delivery. However, their systemic administration still remains a challenge due to their hydrophobic nature with instances of aggregation leading to fast reticuloendothelial system (RES) uptake. In this study, magnetic nanocomposites with thermosensitive polymer have been investigated. Random polymers of N-isopropylacrylamide (NIPAAM), acrylic acid (AA) and PEGMA have been coated on SPIONs followed by conjugation with folic acid. Particles of ∼200 nm and low polydispersity 0.1-0.2 having a critical temperature (T(c)) of 44 °C were formed. Thermogravimetric and powder X-ray diffraction studies showed that the nanocomposites were composed of 90% cubic face-centered magnetite. Nearly 76.5% doxorubicin was loaded onto the nanoparticles by diffusion method. Drug release was higher at the hyperthermia temperature (72.42 ± 5.25% in 48 h) proving the thermoresponsive nature of the polymer. Folate conjugated samples showed a magnetization value of 32 emu/g as well as high r1 and r2 relaxivities in magnetic resonance imaging. R2 weighted images of nanocomposites were darker than the control with 20 μg/mL as the darkest. At this concentration the magnetic composites showed nearly 95% viability in L929 fibroblast cells. These thermoresponsive nanosystems with pegylated surfaces and size of ∼200 nm are therefore highly suitable for in vivo imaging and hyperthermia based drug delivery. |
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Authors:
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Rachna Rastogi; Nany Gulati; Ravinder K Kotnala; Uma Sharma; Rama Jayasundar; Veena Koul |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-09-20 |
Journal Detail:
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Title: Colloids and surfaces. B, Biointerfaces Volume: 82 ISSN: 1873-4367 ISO Abbreviation: Colloids Surf B Biointerfaces Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-24 Revised Date: 2011-09-27 |
Medline Journal Info:
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Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: Netherlands |
Other Details:
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Languages: eng Pagination: 160-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 10016, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Survival / drug effects Diagnostic Imaging* Doxorubicin / pharmacology Fibroblasts / cytology, drug effects Folic Acid / chemistry* Iron / metabolism Magnetics* Mice Nanocomposites / chemistry*, ultrastructure Nanomedicine Neoplasms / diagnosis*, therapy* Particle Size Polyethylene Glycols / chemistry* Spectroscopy, Fourier Transform Infrared Temperature* X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 23214-92-8/Doxorubicin; 59-30-3/Folic Acid; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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