Document Detail


Evaluation of focal cerebral ischemia in rats by magnetic resonance imaging and immunohistochemical analyses.
MedLine Citation:
PMID:  9740095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Correlation of focal ischemia-induced brain damage evidenced by magnetic resonance imaging (MRI) and by staining with microtubule-associated protein 2 (MAP2) was studied in rats. Ischemia was produced by transient occlusion of the middle cerebral artery (MCAO). The damage was assessed at 6 to 8 hours after MCAO and 1 week later. The area of damage assessed by MRI agreed with that by MAP2 staining at 6 to 8 hours after MCAO, which was smaller (P < 0.001) than that defined by MAP2 staining 1 week after MCAO. Glial staining indicated that glial infiltration affected the signal intensity of MRI in the area of damage.
Authors:
H Ishii; T Arai; S Morikawa; T Inubushi; I Tooyama; H Kimura; K Mori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  18     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-02     Completed Date:  1998-10-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-4     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, Kyoto University Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / diagnosis
Evaluation Studies as Topic
Hypertension / pathology
Immunohistochemistry
Ischemic Attack, Transient / diagnosis*,  metabolism
Magnetic Resonance Imaging*
Male
Microtubule-Associated Proteins
Rats
Rats, Inbred SHR
Chemical
Reg. No./Substance:
0/Microtubule-Associated Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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