Document Detail

Evaluation of a fibrin sealant free of bovine-derived components in an experimental vas anastomosis study.
MedLine Citation:
PMID:  11112868     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The risk of transmission of bovine spongiform encephalopathy cannot be excluded from the use of bovine-derived products. The present study was undertaken to evaluate the performance of a new fibrin glue free of bovine-derived components in vas anastomosis and to compare this product to conventional vas anastomosis with fibrin glue. METHODS: Bilateral delayed vas anastomosis was performed in 40 Sprague-Dawley rats. All animals underwent a fibrin glue-assisted vas anastomosis with three transmural sutures tied prior to fibrin glue application. The composition and preparation of fibrin glue was similar for all vas anastomoses except the fibrinolysis inhibitor component which was aprotinin (3,000 KUI/ml) in group 1 and tranexamic acid (10 mg/ml) in group 2. The animals (20 rats in both groups) were sacrificed 7 weeks postoperatively and evaluated for gross patency, presence of sperm granuloma and tensile strength measurements at the anastomosis site. RESULTS: No difference was found between the 2 groups for all parameters evaluated whether a bovine-derived or a synthetic fibrinolysis inhibitor component was used. CONCLUSION: This study showed that tranexamic acid, a fibrinolysis inhibitor, can be substituted for conventional fibrin glue thereby avoiding the risks of bovine products.
O Vankemmel; A de La Taille; T Burnouf; J M Rigot; F Duchene; E Mazeman
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Urologia internationalis     Volume:  65     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  196-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Clinique Urologique, Centre Hospitalier Universitaire, Lille, France.
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MeSH Terms
Anastomosis, Surgical / methods
Disease Models, Animal
Fibrin Tissue Adhesive / pharmacology*
Materials Testing
Rats, Sprague-Dawley
Sensitivity and Specificity
Tensile Strength
Tranexamic Acid / pharmacology*
Vasovasostomy / methods*
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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