Document Detail

Evaluation of fetal heart rate variation during amniocentesis: correlation with fetal karyotype.
MedLine Citation:
PMID:  20828234     Owner:  NLM     Status:  In-Data-Review    
Objective. We monitored the fetal heart rate (FHR) during amniocentesis in fetuses at 16-18 weeks of gestation and investigated whether an abnormal FHR is associated with chromosomal abnormalities. Methods. This prospective study involves 807 women at 16-18 weeks of gestation who underwent genetic amniocentesis. The FHR, expressed as beats for minute, is recorded before (FHR1), immediately after (FHR2) and 60 min after (FHR3) the invasive procedure. Structural malformations detected by ultrasound and multiple pregnancy are excluded from the study. Results. Chromosomal abnormalities have been diagnosed in 27 fetuses. A mean FHR decrease after amniocentesis has been observed in normal and in abnormal fetuses. The mean variation during amniocentesis is significant in both groups (P < 0.01). The comparison between the mean FHR of the two groups shows no differences in FHR1 and FHR2 (P > 0.05) but a significant difference in FHR3 (P < 0.05). Conclusion. The FHR decreases after amniocentesis; the decrease is larger in chromosomally abnormal fetuses than in normal fetuses. This difference in heart rate reaction to amniocentesis might be due to cardiac defects or developmental delay associated with the abnormal karyotype.
Adalgisa Pietropolli; Federica Martelli; Roberta Vicario; Carlotta Montagnoli; Carlo Ticconi; Emilio Piccione
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Publication Detail:
Type:  Journal Article     Date:  2010-09-09
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  24     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Rome, Rome, Italy.
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