Document Detail

Evaluation of fetal cerebrovascular circulation and brain development: the role of ultrasound and Doppler.
MedLine Citation:
PMID:  19631086     Owner:  NLM     Status:  MEDLINE    
The human fetal brain is protected from pressure changes by autoregulation of the cerebral circulation. However, antenatal intrauterine cerebrovascular events are found to play an important role in the pathogenesis of perinatal brain damage. Changes in placental vascular resistance, cardiac contractibility, vessel compliance, and blood viscosity alter the normal dynamics of fetal cerebral circulation. The introduction of various sonographic techniques and the collection of data from the arterial and venous cerebral circulation provide a powerful tool for the evaluation of physiological and pathological hemodynamic events. Anatomic and physiological considerations of cerebral vasculature in healthy and disease states are relevant in studying brain development and variations in fetal brain blood perfusion. The major role of ultrasound and Doppler modalities in the evaluation of fetal cerebrovascular circulation is enabled by implementation of these considerations. Changes in flow characteristics in fetal cerebral vasculature can be used for clinical decision making in situations of fetal compromise, such as growth restriction and anemia.
Shimon Degani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in perinatology     Volume:  33     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-69     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Bnei Zion Medical Center, Ruth and Baruch Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel.
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MeSH Terms
Brain / abnormalities*,  blood supply*,  embryology
Circle of Willis / abnormalities,  embryology,  ultrasonography*
Fetal Growth Retardation / ultrasonography
Intracranial Arteriovenous Malformations / ultrasonography
Ultrasonography, Doppler, Transcranial*
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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