| Evaluation of femoral perfusion in a non-traumatic rabbit osteonecrosis model with T2*-weighted dynamic MRI. | |
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MedLine Citation:
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PMID: 12568968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated femoral perfusion in a non-traumatic rabbit serum sickness osteonecrosis (ON) model, using serial repetitive T2*-weighted (T2*W) dynamic magnetic resonance imaging (MRI) and investigated prediction of ON occurrence in early stages, comparing T2*W dynamic MRI with non-enhanced (T2-, T1- and fat suppression T1-weighted) and contrast-enhanced MRI. Early microcirculatory injury or necrotic lesion was detected in 0% of femora (extravasation, 0/6) at 72 h, 33% (necrotic, 4/12) at 1 week and 100% (necrotic, 14/14) at 3 weeks using non-enhanced MRI, and in 67% of femora (extravasation, 4/6) at 72 h, 58% (necrotic, 7/12) at 1 week and 100% (necrotic, 14/14) at 3 weeks using contrast-enhanced MRI. In contrast, microcirculatory injury or necrotic lesion was detected in 83% of femora (extravasation, 5/6) at 72 h, 92% (necrotic, 11/12) at 1 week and 100% (necrotic, 14/14) at 3 weeks using T2*W dynamic MRI as no transient decrease or less marked transient decrease in signal intensity of regions of interest (ROIs), compared to normal femora, which showed a clear transient decrease in signal intensity of ROIs. These results indicate that T2*W dynamic MRI with optimal imaging parameters and a dose of contrast agent is the most sensitive of these three MRI methods and may be clinically useful for evaluating femoral perfusion in artery phase and predicting ON occurrence. |
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Authors:
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Takashi Tsuji; Nobuhiko Sugano; Takashi Sakai; Hideki Yoshikawa |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 21 ISSN: 0736-0266 ISO Abbreviation: J. Orthop. Res. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-05 Completed Date: 2003-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: United States |
Other Details:
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Languages: eng Pagination: 341-51 Citation Subset: IM |
Affiliation:
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Diagnostics Research Support, Preclinical Development Department, Nihon Schering, 2-6-64, Nishimiyahara, Yodogawa-ku, Osaka 532-0004, Japan. ttsuji@schering.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Femur / blood supply, pathology* Gadolinium DTPA / diagnostic use Magnetic Resonance Imaging / methods* Male Osteonecrosis / diagnosis*, etiology Rabbits |
| Chemical | |
Reg. No./Substance:
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80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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