| Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes. | |
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MedLine Citation:
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PMID: 19889270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare different cut-off values of fasting and random plasma glucose as a screening test for diagnosis of gestational diabetes in comparison to the 50 grams Glucose Challenge Test (GCT). STUDY DESIGN: Comparative, cross-sectional study. PLACE AND DURATION OF STUDY: This study was carried out between July 2006 to September 2007 at Departments of Pathology, Obstetrics/Gynaecology and Medicine, PNS Rahat Hospital, Karachi. METHODOLOGY: A total of 53 pregnant subjects at 24-28 weeks of pregnancy were selected to undergo random and fasting blood sugar level estimation and 50-g GCT. All the subjects later underwent 100-g OGTT as well. The results were evaluated by both "Carpenter and Coustan criteria" and "NDDG criteria". The results of random plasma glucose random [cut-off: > or = 11.1 mmol/L], fasting plasma glucose (cut-off: > 5.3 mmol/L and > 5.1 mmol/L) and plasma glucose results post 50-g GCT (cut-off: > or =7.8 mmol/L and > or = 7.2 mmol/L) were evaluated against 100-g OGTT results through ROC curve analysis. Finally, various diagnostic parameters including sensitivity, specificity, predictive values, likelihood ratios (LR) and efficiency were evaluated. RESULTS: Nineteen subjects were diagnosed to have GDM as per the "Carpenter and Coustan criteria" and 13 met the "NDDG criteria" as per the results of 100-g OGTT. Fasting plasma glucose at was the most efficient investigation at cutoff of 5.1 mmol/L sensitivity=66.66%, specificity=81.25%, PPV=70%, NPV=78.78%, LR+=3.56, LR-=0.41, efficiency=75.47%. At the cut-off value of 5.3 mmol/L, the results had 64% sensitivity, 85.71% specificity, 80% PPV, 72.72% NPV, 4.48 LR+, 0.42 LR-, 75.97% efficiency]. It was followed by plasma glucose post 50-g GCT (53.57% sensitivity at cut-off of > or = 7.2 mmol/L and 54.54% sensitivity at cut-off of > or = 7.8 mmol/L). CONCLUSION: Fasting plasma glucose is a better investigation for the screening of gestational diabetes than plasma glucose post 50-g glucose challenge. |
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Authors:
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Sikandar Hayat Khan; Farah Sadia; Humaira Arshad; Aamer Khalil |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Volume: 19 ISSN: 1022-386X ISO Abbreviation: J Coll Physicians Surg Pak Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606447 Medline TA: J Coll Physicians Surg Pak Country: Pakistan |
Other Details:
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Languages: eng Pagination: 718-22 Citation Subset: IM |
Affiliation:
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Department of Pathology, PNS Rahat Hospital, Karachi. sik_cpsp@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Blood Glucose / analysis* Cross-Sectional Studies Diabetes, Gestational / diagnosis* Fasting / blood Female Glucose Tolerance Test Humans Pregnancy Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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