| Evaluation of extraocular muscles using dynamic contrast enhanced MRI in patients with chronic thyroid orbitopathy. | |
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MedLine Citation:
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PMID: 15665696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of the current study is to investigate the underlying pathophysiological changes of extraocular muscle (EOM) in Graves orbitopathy using dynamic contrast MR imaging and to correlate these MR functional changes with the anatomic abnormalities. METHODS: EOMs of 16 patients with Graves disease and 12 normal volunteers were examined by dynamic enhanced MRI. We quantified the peak enhancement ratio of EOMs and calculated the ratio versus temporalis muscle and the ratio of maximum upslope versus temporalis muscle. We compared the ratios between normal volunteers and patient groups. RESULTS: Mean of peak enhancement ratio values for the EOMs in patients with Graves disease tends to decrease according to the severity of the anatomic and clinical changes. The mean maximum upslope also decreased according to the severity of the disease for EOMs. CONCLUSION: Hemodynamic information obtained by dynamic contrast enhanced MRI is useful in evaluating the clinical course of thyroid orbitopathy. |
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Authors:
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Toshiaki Taoka; Masahiko Sakamoto; Hiroyuki Nakagawa; Akio Fukusumi; Satoru Iwasaki; Keiko Taoka; Kimihiko Kichikawa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 29 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-01-24 Completed Date: 2005-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: IM |
Affiliation:
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Department of Radiology, Nara Medical University, Nara, Japan. ttoaka@naramed-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Contrast Media* Exophthalmos / physiopathology Gadolinium DTPA / diagnostic use Graves Disease / physiopathology* Humans Hypertrophy Image Enhancement / methods* Magnetic Resonance Imaging / methods* Middle Aged Oculomotor Muscles / physiopathology* Sensitivity and Specificity Temporal Muscle / physiopathology Thyrotropin / blood Thyroxine / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7488-70-2/Thyroxine; 80529-93-7/Gadolinium DTPA; 9002-71-5/Thyrotropin |
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