| Evaluation of exercise-induced changes in concentrations of C-reactive protein and serum biochemical values in sled dogs completing a long-distance endurance race. | |
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MedLine Citation:
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PMID: 20919909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether long-distance endurance exercise in sled dogs causes increases in serum concentrations of C-reactive protein (CRP) and whether such increases are correlated with other markers of the exercise-induced acute-phase response. ANIMALS: 25 sled dogs. PROCEDURES: Serum was obtained from 25 sled dogs approximately 48 hours before and immediately after completing a race of 557 km. Serum was analyzed to determine concentrations of CRP and interleukin (IL)-6, and serum biochemical analysis (and iron homeostasis analysis) also was performed. RESULTS: CRP concentrations increased significantly from a mean±SD concentration of 22.4±16.3 microg/mL before racing to a mean of 263.3±103.8 microg/mL immediately after racing Serum IL-6 concentrations were unchanged; however, there was a modest but significant correlation (r=0.50) between the increase in CRP concentration and an overall decrease in serum albumin concentration, which suggested an inverse relationship between hepatic synthesis of the 2 proteins. Differences in CRP concentrations among teams of dogs revealed that concentrations before racing may be influenced by previous episodes of exercise. Serum iron concentration had only a mild decrease, which may have been attributable to iron-rich diets consumed by the dogs. CONCLUSIONS AND CLINICAL RELEVANCE: CRP concentrations may serve as a potential marker for exercise-induced inflammation. The exact amount of exercise required to induce such a response is unknown, but dogs apparently have a more robust acute-phase response than do humans. Clinical evaluation of CRP concentrations must account for physical activity when those concentrations are used as a potential marker for systemic inflammation. |
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Authors:
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Joseph J Wakshlag; Tracy Stokol; Susan M Geske; Cara E Greger; Craig T Angle; Rob L Gillette |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 71 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 1207-13 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, College of Veterinary Medicine, Cornell University Ithaca, NY 14853, USA. jw37@cornell.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals C-Reactive Protein / metabolism* Dogs / blood*, physiology* Interleukin-6 / blood, metabolism Physical Conditioning, Animal / physiology* Physical Endurance / physiology* Sports Tumor Necrosis Factor-alpha / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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