Document Detail


Evaluation of exclusion prenatal and exclusion preimplantation genetic diagnosis for Huntington's disease in the Netherlands.
MedLine Citation:
PMID:  23137131     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Individuals at 50% risk of Huntington's disease (HD) who prefer not to know their carrier status, might opt for exclusion prenatal diagnosis (ePND) or exclusion preimplantation genetic diagnosis (ePGD). This study aims to provide a better understanding of couples' motives for choosing ePND or ePND, and surveys couples' experiences in order to make recommendations for the improvement of counselling for exclusion testing. METHOD: Qualitative retrospective interview study on couples who underwent ePND or ePGD for Huntington's disease in the period 1996-2010. RESULTS: Seventeen couples were included: 13 had experienced ePND and six ePGD. Mean time-interval since exclusion-testing was 3.9 years. Couples' moral reservations regarding termination of pregnancy (TOP) or discarding healthy embryos were counterbalanced by the wish to protect their future child against HD. Seven couples had terminated a total of 11 pregnancies with a 50% HD risk, none showed regret. ePGD was used by couples who wanted to avoid (another) TOP. CONCLUSION: ePND and ePGD are acceptable reproductive options for a specific group of counsellees. To guarantee sound standards of care, it is imperative that candidate couples be given in-depth non-directive counselling about all possible scenarios, and adequate professional and psychological support prior to, during and after ePND/ePGD.
Authors:
M C van Rij; C E M de Die-Smulders; E K Bijlsma; G M W R de Wert; J P Geraedts; R A C Roos; A Tibben
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Clinical genetics     Volume:  -     ISSN:  1399-0004     ISO Abbreviation:  Clin. Genet.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Dept. Clinical Genetics, Maastricht University Medical Centre MUMC+; Dept. Neurology, Leiden University Medical Centre LUMC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  N-Acylated Dipeptide Tags Enable Precise Measurement of Ion Temperature in Peptide Fragmentation.
Next Document:  Patient and tumour-related factors for prediction of urinary incontinence after radical prostatectom...