| Evaluation of eugenol for mutagenicity by the mouse micronucleus test. | |
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MedLine Citation:
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PMID: 3100745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mutagenicity of eugenol (2-methoxy-4-allylphenol) was evaluated by an in vivo eukaryotic assay in mice. A 50% lethal dose (LD50) for intraperitoneal (IP) delivery of eugenol was found to be 1109.6 mg/kg body weight (7.5% eugenol-in-saline). Oral (PO) delivery via stainless-steel, esophageal cannulation was not lethal to 14,794 mg/kg body weight (100%) eugenol. Based upon recommended procedure, 80 and 25% LD50 doses were administered IP in 250 microliter volumes. Undiluted eugenol was administered PO in 100 microliter volumes. Delivery of eugenol by both regimes to male mice induced anaphase mutations in polychromatic erythrocytes as measured by the bone marrow micronucleus test. IP delivery of both doses induced the formation of micronuclei to significant levels (P less than 0.001) compared to saline controls. PO delivery of eugenol induced a much reduced frequency of micronuclei when compared to the IP route. However, a significant increase in micronuclei was evident when this test population was compared to its control group (P less than 0.003). These results suggest that eugenol presents some mutagenic capacity in eukaryotic hosts and should be evaluated for further toxicological effects. |
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Authors:
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C J Woolverton; P G Fotos; M J Mokas; M E Mermigas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of oral pathology Volume: 15 ISSN: 0300-9777 ISO Abbreviation: J. Oral Pathol. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-03-06 Completed Date: 1987-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342050 Medline TA: J Oral Pathol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 450-3 Citation Subset: D; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bone Marrow / drug effects Cell Nucleus / drug effects Eugenol / administration & dosage, toxicity* Lethal Dose 50 Male Mice Mice, Inbred Strains Mutagenicity Tests / methods* |
| Chemical | |
Reg. No./Substance:
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97-53-0/Eugenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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